Studies with enamines: Functionally substituted enamines as aldehyde equivalents in Gewald reaction

Acetylation of Some Cyclic Enamines With Substituted Acetyl Chlorides

Acylation reaction of a variety of cyclic ketones via acylation of the corresponding enamines is welldefined in the literature. Enamine acylation of carbonyl compounds is a significant synthetic method because of its mildness and the ease of preparing various β-diketones [1-4]. Acylation reactions are performed by means of converting enamines to the enaminoketones and subsequent hydrolysis of t...

Studies with Enamines: Route to Aminoazolopyrimidines and Arylazoazolopyrimidines

The chemistry of azolopyrimidines has in the past received considerable interest [1 – 5] and is still an area of major interest [6, 7]. Recently azoloazines have been shown to be of antimicrobial, antioxidant [8] and agrochemical importance. Moreover they are a promising new class of dyes for D2T2 printing and hair dyes [9, 10]. Microwave heating has been employed as a frequent resource for the...

Reaction of heterocyclic enamines with nitrile oxide and nitrilimine precursors.

Alkylidenepyrrolidines 1, 21, 24 and 26 undergo reactions with nitrile oxides and nitrilimines or their precursors to give a range of novel heterocyclic compounds. With alkylidenepyrrolidine ester 1, nitrolic acids give products in which the liberated nitrous acid reacts with the alkylidenepyrrolidine, followed by two cycloadditions to give adducts 3. In contrast, hydroximoyl chlorides give iso...

Crystal structures of proline-derived enamines.

The isolation and structural characterization of both aldehyde- and ketone-derived proline enaminones are reported and discussed. Crystal structures of 10 proline enamines provide information on stereochemical aspects, i.e., double bond configuration and syn- vs. anti-positioning of the carboxylate relative to the enamine double bond. Furthermore, the obtained crystal structures are compared wi...

Synthesis of enamines and their bromination